2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-12753AR
    Debutyldronedarone hydrochloride (Standard) 197431-02-0
    Debutyldronedarone (hydrochloride) (Standard) is the analytical standard of Debutyldronedarone (hydrochloride). This product is intended for research and analytical applications. Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic.
    Debutyldronedarone hydrochloride (Standard)
  • HY-12753AS
    Debutyldronedarone-d7 hydrochloride 98%
    Debutyldronedarone-d7 hydrochloride is deuterated labeled Debutyldronedarone hydrochloride (HY-12753A). Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic.
    Debutyldronedarone-d7 hydrochloride
  • HY-12753S1
    Debutyldronedarone-d6 hydrochloride 1346598-70-6 98%
    Debutyldronedarone-d6 (hydrochloride) is deuterium labeled Debutyldronedarone. Debutyldronedarone is a major circulating active metabolite of dronedarone (HY-A0016) in humans. Debutyldronedarone exhibits a potency that is 1/10 to 1/3 of that of the parent agent.
    Debutyldronedarone-d6 hydrochloride
  • HY-12765S1
    Losartan carboxylic acid-d4 hydrochloride 98%
    Losartan carboxylic acid-d4 (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.
    Losartan carboxylic acid-d4 hydrochloride
  • HY-12773AS
    5-Hydroxy Propafenone-d5 hydrochloride 1215370-87-8 98%
    5-Hydroxy Propafenone-d5 (hydrochloride) is the deuterium labeled 5-Hydroxy Propafenone.
    5-Hydroxy Propafenone-d5 hydrochloride
  • HY-12798CR
    AR-13503 (Standard) 2309668-15-1
    Fluanisone (Standard) is the analytical standard of Fluanisone. This product is intended for research and analytical applications. Fluanisone has potent sedative effect in vivo. Fluanisone can be used to study schizophrenia.
    AR-13503 (Standard)
  • HY-128483R
    Fusaric acid (Standard) 536-69-6
    Fusaric acid (Standard) is the analytical standard of Fusaric acid (HY-128483). This product is intended for research and analytical applications. Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β1/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer.
    Fusaric acid (Standard)
  • HY-128544A
    Proroxan hydrochloride 33025-33-1 98%
    Proroxan hydrochloride is a non-selective adrenergic α-antagonist. Proroxan hydrochloride can be used in the study of hypertension.
    Proroxan hydrochloride
  • HY-128696R
    Amlodipine aspartic acid impurity (Standard) 400602-35-9
    Amlodipine aspartic acid impurity (Amlodipine aspartate) (Standard) is the analytical standard of amlodipine aspartic acid impurity. This product is intended for research and analytical applications. Amlodipine aspartic acid impurity is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension.
    Amlodipine aspartic acid impurity (Standard)
  • HY-128850R
    N-Acetyl-D-mannosamine (Standard) 3615-17-6
    N-Acetyl-D-mannosamine (Standard) is an analytical standard for N-Acetyl-D-mannosamine. This product is intended for research and analytical applications. N-Acetyl-D-mannosamine (ManNAc) is an orally active sialic acid (Sialic Acid) precursor that can prevent hypertension by increasing sialylation of IgG and has potential for use in cardiovascular disease research. N-Acetyl-D-mannosamine activates hypocretin (HCRT) gene expression and alters
    N-Acetyl-D-mannosamine (Standard)
  • HY-129029R
    Bisoprolol (Standard) 66722-44-9
    Bisoprolol (Standard) is the analytical standard of Bisoprolol. This product is intended for research and analytical applications. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.
    Bisoprolol (Standard)
  • HY-129953A
    5-trans Prostaglandin F2α 36150-01-3 98%
    5-trans Prostaglandin F2α is an endogenous metabolite present in Blood that can be used for the research of Myocardial Infarction.
    5-trans Prostaglandin F2α
  • HY-129953C
    5-trans Prostaglandin F2α tromethamine 330796-56-0 98%
    5-trans Prostaglandin F2α tromethamine is a derivative of 5-trans Prostaglandin F2α (HY-129953A). 5-trans Prostaglandin F2α is an endogenous metabolite present in blood that can be used for the research of myocardial infarction.
    5-trans Prostaglandin F2α tromethamine
  • HY-130319A
    9-HEPE 286390-03-2 98%
    9-HEPE, a oxidation product of Eicosapentaenoic acid, is a racemic mixture of 9(R)-HEPE and 9(S)-HEPE. 9-HEPE induces fatty acid oxidation, adipogenesis, and glucose uptake via activation of PPARs in vivo.
    9-HEPE
  • HY-130353R
    Desethylamiodarone hydrochloride (Standard) 96027-74-6
    Desethylamiodarone (hydrochloride) (Standard) is the analytical standard of Desethylamiodarone (hydrochloride). This product is intended for research and analytical applications. Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
    Desethylamiodarone hydrochloride (Standard)
  • HY-130353S
    Desethyl Amiodarone-d4 hydrochloride 1189960-80-2 98%
    Desethyl Amiodarone-d4 (hydrochloride) is the deuterium labeled Desethylamiodarone hydrochloride. Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
    Desethyl Amiodarone-d4 hydrochloride
  • HY-130778R
    N,N'-Diacetylchitobiose (Standard) 35061-50-8
    N,N'-Diacetylchitobiose (Standard) is the analytical standard of N,N'-Diacetylchitobiose. This product is intended for research and analytical applications. N,N'-Diacetylchitobiose is a dimer of β(1,4) linked N-acetyl-D glucosamine. N,N'-Diacetylchitobiose is the hydrolysate of chitin and can be used as alternative carbon source by E. coli. N,N'-Diacetylchitobiose also reverses myocardial depression.
    N,N'-Diacetylchitobiose (Standard)
  • HY-131105R
    Cimbuterol (Standard) 54239-39-3
    Cimbuterol (Standard) is the analytical standard of Cimbuterol (HY-131105). This product is intended for research and analytical applications. Cimbuterol is a β-adrenergic receptor agonist that can promote growth in pork.
    Cimbuterol (Standard)
  • HY-131105S
    Cimbuterol-d9 1246819-04-4 98%
    Cimbuterol-d9 is the deuterium labeled Cimbuterol (HY-131105). Cimbuterol is a β-adrenergic receptor agonist that can promote growth in pork.
    Cimbuterol-d9
  • HY-131515R
    Tri-Salicylic acid (Standard) 85531-17-5
    Tri-Salicylic acid (Standard) is the analytical standard of Tri-Salicylic acid. This product is intended for research and analytical applications. Tri-Salicylic acid is the compound with similar properties of salicylic acid. Tri-Salicylic acid has the potential for the research of inflammation, obesity and cardiovascular diseases (extracted from patent US20170368079A1, compound III).
    Tri-Salicylic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity